| Side panel | Magnetic 12-, 6- and 2-button plates | Fixed 12-button panel | Pro changes the number of side buttons. |
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| Index-edge controls | Extra top buttons sit behind the wheel | Two buttons beside left click | HyperSpeed puts two controls at the index finger. |
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| Weight | 134 g with 12-button plate | 95 g without AA; about 118 g with included alkaline AA measured by TechPowerUp | HyperSpeed is lighter without its battery; installed, the gap narrows. |
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| Power and connections | Rechargeable; USB-C, 2.4 GHz and Bluetooth | Replaceable AA; 2.4 GHz and Bluetooth | Pro can use a cable; HyperSpeed runs on AA. |
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| Rated battery life | Up to 150 h on 2.4 GHz or 300 h on Bluetooth | Up to 250 h on 2.4 GHz or 400 h on Bluetooth | HyperSpeed has higher published maximums. |
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| Main switches | Razer Optical Mouse Switches Gen-3 | Razer Mechanical Mouse Switches Gen-2 | Different switch designs; neither predicts a specific lifespan. |
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| Scroll wheel | HyperScroll Pro with adjustable tension and left/right tilt | Free-spin/tactile wheel with left/right tilt | Pro adds software adjustment. |
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