Setting it up for games
Any PC game
Put Discord mute, clip capture, audio device switch, and music on the first page. Let Smart Profiles on the Neo or Dynamic Mode on the Controller X load a game's page when it has focus. Keep your rotation or combat keys on keyboard and mouse.
WoW
Eight keys suit one raid-utility page: skull, cross, ready check, pull timer, mount, hearth, Discord mute, and clip. Put the other markers on a second page reached with a Touch Point. Team Echo's WoW profile was built for the MK.2, but Elgato says it works on other Stream Deck models, so the Neo can run it with paging. Install the Echo Stream Deck Tools addon first.
Bind actions in WoW's Key Bindings to combos you won't hit by accident and point one Hotkey action at each. See the WoW Stream Deck setup guide.
FFXIV
In FFXIV, r/ffxiv players put macros and gearset swaps on Stream Deck keys, and 8 keys cover a job's worth; see the FFXIV setup hub.